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Estimated Wasteful Spending on Aducanumab Dishing out within the U.S. Medicare Inhabitants: A Cross-Sectional Evaluation

Aducanumab, a weight-dosed Alzheimer’s drug with unsure advantages and excessive value, might pressure Medicare’s finances if authorised for widespread use. In April 2022, Medicare issued a remaining willpower limiting aducanumab’s use to scientific trials. Nevertheless, Medicare’s protection choice should still be overturned by authorized challenges, doubtlessly resulting in a lot increased uptake. Furthermore, a number of different Alzheimer’s infusion medicine much like aducanumab are at the moment within the improvement pipeline.

As a result of aducanumab is on the market in two fixed-dose vial sizes, its use might lead to giant quantities of discarded drug and wasteful spending. To quantify the quantity of discarded drug and potential financial savings that might be generated from extra environment friendly aducanumab vial sizes, we analyzed affected person weight distributions from a nationally consultant pattern of Medicare beneficiaries with delicate cognitive impairment (MCI) or delicate dementia.

This report is a part of the RAND Company Exterior publication collection. Many RAND research are revealed in peer-reviewed scholarly journals, as chapters in business books, or as paperwork revealed by different organizations.

The RAND Company is a nonprofit establishment that helps enhance coverage and decisionmaking by means of analysis and evaluation. RAND’s publications don’t essentially mirror the opinions of its analysis purchasers and sponsors.

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